Effect of Taurine and Curcumin on In-Vitro Fertilization in NMRI Mice Treated with Acrylamide

Introduction: The aim of this study was to evaluate the effect of taurine and curcumin on in vitro fertilization (IVF) in female mice treated with acrylamideand and its effect on malondialdehyde (MDA) concentration and total antioxidant capacity (TAC). Methods: A total of 48 adult female NMRI mice were randomly divided into 6 groups, including control, curcumin 200 mg / kg, taurine 150 mg / kg, acrylamide 5 mg / kg, acrylamide 5 mg / kg + curcumin 100 and 200, acrylamide 5 mg / kg + Taurine 75 and 150 mg / kg.  The drugs were administered orally for 35 days, and then IVF rate, MDA and TAC concentrations were examined in each group.   Results: The results showed a significant decrease in oocyte, fertilization percentage, 2, 4 and 8 cell, Compact and blastocytes embryos in the acrylamide group compared to the control (P<0.05). In acrylamide group, MDA concentration increased and TAC showed a significant decrease compared to other groups (P<0.05). There was a significant increase in oocyte count and fertilization percentage in taurine group compared to the control (P‌<0.001). A significant increase in the above parameters was observed in the acrylamide + taurine group at a dose of 150 mg / kg compared to the acrylamide group (P<0.05). Percentage of fertilization and embryos of 2, 4 and 8 cells, Compact and blastocytes in the curcumin group showed a significant decrease compared to the control (P<0.05). Conclusion: The results indicate that taurine has a better performance in reducing the side effects of acrylamide than curcumin. Since curcumin can prevent IVF, it should be used with more caution at the beginning of pregnancy.